Research Overview
My laboratory is investigating a number of questions involving plants, including their remarkable capacity to produce a complex array of interesting compounds, the way they respond to pathogens and disease, and also the feasibility of engineering their biosynthetic apparatus for applications ranging from human health to biofuel production.
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Research Description
Research Interests: Gene-metabolite relationships in medicinal plants; molecular basis for plant disease resistance, plant metabolic engineering for improved biofuel production
1) Metabolic Engineering of Secondary Metabolite Synthesis in Medicinal Plants of Appalachia
2) Allosteric Motor Proteins Involved in Plant Disease Resistance
3) Engineering Designer Lignins for Improved Production of Cellulosic Biomass for Biofuels
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Representative Publications
David G. Myszka, Yasmina N. Abidiche, Fumio Arisaka, Olwyn Byron, Edward Eisenstein, Preston Hensley, James A. Thomson, Christian R. Lombardo, Frederick Schwarz, Walter Stafford and Michael L. Doyle (2003) “The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction,” J. Biomolecular Techniques 14, 247-269.
D. Cheon Yeh, James F. Parsons, Lisa M. Parsons, F. Liu, Edward Eisenstein and John Orban (2004) “NMR assignment of the hypothetical protein HI0004 from Haemophilus influenzae, a putative essential gene product,” J. Biomol. NMR 29, 101-102.
James F. Parsons, Fenhong Song, Lisa Parsons, Kelly Calabrese, Edward Eisenstein and Jane E. Ladner (2004) “Structure and Function of the Phenazine Biosynthesis Protein PhzF from Pseudomonas fluorescens 2-79,” Biochemistry, 43, 12427-12435.
D.Travis Gallagher, Dianna Chinchilla, Heidi Lau and Edward Eisenstein (2004) “Local and global control mechanism in allosteric threonine deaminase,” Methods in Enzymology 380, 85-106.
Iva Naratilova, Edward Eisenstein, David G. Myszka (2005) “Measuring Long Association Phases using Biacore,” Analytical Biochemistry 344, 295-297.
Asim K. Bera, Vesna Atanasova, Howard Robinson, Edward Eisenstein, James P. Coleman, Everett C. Pesci and James F. Parsons (2009) “Structure of PqsD, A Pseudomonas Quinolone Signal Bioynthetic Enzyme, in Complex with Anthranilate,” Biochemistry 48, 8644-8655.
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